Avhandling
Holm I (1988) Regulation of ornithine decarboxylase expression in mammalian cells. Doctoral dissertation. Dept. of Zoophysiology, University of Lund.
 
Bokkapitel
1. Persson L, Holm I and Heby O (1987) Ornithine decarboxylase mRNA expression and translation. In: Advances in Gene Technology: The Molecular Biology of Development. ICSU Short Reports, Vol 7 (Voellmy RW, Ahmad F, Black S, Burgess DR, Rotundo R, Scott WA and Whelan WJ, eds) Cambridge University Press, p 25.

2. Persson L, Holm I, Stjernborg L and Heby O (1988) Regulation of poly-amine synthesis in mammalian cells. In: Progress in Polyamine Research. Novel Biochemical, Pharmacological, and Clinical Aspects (Zappia V and Pegg AE, eds) Plenum Press, New York, pp 261-271.

3. Heby O, Persson L, Holm I and Ask A (1990) Cure of mouse leukemia by polyamine depletion. In: The Biology and Chemistry of Polyamines (Goldemberg SH and Algranati I, eds) Oxford Univ Press, pp 221-226.

4. Persson L, Autelli R, Stjernborg L, Holm I, Khomutov AR, Khomutov RM and Heby O (1990) Feedback regulation of polyamine synthesis in mammalian cells. In: The Biology and Chemistry of Polyamines (Goldemberg SH and Algranati I, eds) Oxford Univ Press, pp 49-59.

5. Heby O, Holm I, Frostesjö L, Collin H, Grahn B, Rehnholm A, Stjernborg L, Ask A and Persson L (1992) Polyamines: regulators of mammalian cell growth and differentiation. In: Polyamines in the gastrointestinal tract - Falk Symposium No. 62 (Dowling, R H, Fölsch, U R and Löser, Chr, eds) Kluwer Academic Publishers, Lancaster, UK, pp 19-28.

6. Persson L, Lövkvist E, Stjernborg L, Ask A, Holm I and Heby O (1992) Regulatory mechanisms in polyamine metabolism. In: Polyamines in the gastrointestinal tract - Falk Symposium No. 62 (Dowling, R H, Fölsch, U R and Löser, Chr, eds) Kluwer Academic Publishers, Lancaster, UK, pp 389-399.
 
Artiklar i vetenskapliga tidskrifter
1. Persson L, Holm I and Heby O (1986) Translational regulation of ornithine decarboxylase by polyamines. FEBS Letters 205:175-178.

2. Löwkvist B, Oredsson SM, Holm I, Emanuelsson H and Heby O (1987) Inhibition of polyamine synthesis reduces the growth rate and delays the expression of differentiated phenotypes in primary cultures of embryonic mesoderm from chick. Cell Tissue Res 249: 151-160.

3. Persson L, Holm I and Heby O (1988) Regulation of ornithine decarboxylase mRNA translation by polyamines. Studies using a cell-free system and a cell line with an amplified ornithine decarboxylase gene. J Biol Chem 263: 3528-3533.

4. Persson L, Holm I, Ask A and Heby O (1988) Curative effect of DL--difluoromethylornithine on mice bearing mutant L1210 leukemia cells deficient in polyamine uptake. Cancer Res 48: 4807-4811.

5. Holm I, Persson L, Heby O and Seiler N (1988) Feedback regulation of polyamine synthesis in Ehrlich ascites tumor cells. Analysis using nonmetabolizable derivatives of putrescine and spermine. Biochim Biophys Acta 972: 239-248.

6. Holm I, Persson L, Stjernborg L, Thorsson L and Heby O (1989) Feedback control of ornithine decarboxylase expression by polyamines. Analysis of ornithine decarboxylase mRNA distribution in polysome profiles and of translation of this mRNA in vitro. Biochem J 258: 343-350.

7. Persson L, Stjernborg L, Holm I and Heby O (1989) Polyamine-mediated control of mammalian S-adenosyl-L-methionine decarboxylase expression: Effects on the content and translational efficiency of the mRNA. Biochem Biophys Res Commun 160: 1196-1202.

8. Holm I, Persson L, Pegg AE and Heby O (1989) Effects of S-adenosyl-1,8-diamino-3-thiooctane and S-methyl-5'-methylthioadenosine on poly-amine synthesis in Ehrlich ascites tumour cells. Biochem J 261: 205-210.

9. Stanley B, Pegg A E and Holm I (1989) Site of pyruvate formation and processing of mammalian S-adenosylmethionine decarboxylase pro-enzyme. J Biol Chem, 264: 21073-21079.

10. Wallon M, Holm I, Thorsson L, Oredsson SM and Heby O (1990) Residual proliferative capacity in F9 teratocarcinoma stem cell cultures treated with -difluoromethylornithine, an inducer of parietal endo-derm differentiation. Cancer Lett 50: 103-107.

11. Autelli R, Holm I, Heby O and Persson L (1990) Feedback regulation of ornithine decarboxylase expression: Studies using a polysomal run-off system. FEBS Lett, 260:39-41.

12. Heby O, Holm I and Persson L (1990) Polyamine-mediated control of ornithine decarboxylase and S-adenosylmethionine decarboxylase expression in mammalian cells. Biochem Soc Transact, 18:1084-1087.

13. Stjernborg L, Heby O, Holm O and Persson L (1991) On the translational control of ornithine decarboxylase expression by polyamines. Biochim Biophys Acta, 1090:188-194.

14. Persson L, Autelli R, Stjernborg L, Holm I and Heby O (1991) Regulation of mammalian S-adenosylmethionine decarboxylase. Life Chemistry Reports 9: 35-41.

15. Shantz L M, Holm I, Jänne O A and Pegg A E (1992) Regulation of S-adenosylmethionine decarboxylase activity by alterations in the intracellular polyamine content. Biochem J, 288:511-518.

16. Ask A, Persson L, Rehnholm A, Frostesjö L, Holm I and Heby O (1993) Development of resistance to hydroxyurea during treatment of human myelogenous leukemia K562 cells with alpha-difluoromethylornithine as a result of co-amplification of the genes for ornithine decarboxylase and ribonucleotide reductase R2 subunit. Cancer Res, 53:1-7.

17. Persson K, Holm I and Heby O (1995) Cloning and sequencing of an intronless mouse S-adenosylmethionine decarboxylase gene coding for a functional enzyme strongly expressed in the liver. J Biol Chem, 270:5642-5648.

18. Gritli-Linde A, Holm I and Linde A (1995) Localization of S-adenosylmethionine decarboxylase in murine tissues by immunohistochemistry. Eur J Oral Sci, 103:133-140.

19. Rosander U C, Holm I, Grahn B, Løvtrup-Rein H, Mattsson M-O and Heby O (1995) Down-regulation of ornithine decarboxylase by a change in enzyme turnover during early gastrulation of Xenopus. Bioch Biophys Acta, 1264:121-128.

20. Lindström P, Bergh A., Holm I and Damber, J-E (1996) Expression of TGF-B1 mRNA in rat ventral prostate and Dunning R3327 PAP prostate tumor after castration and estrogen treatment. Prostate, 29:209-18.

21. Frostesjö L, Holm I, Grahn B, Page AW, Bestor TH and Heby O (1997) Interference with DNA methyltransferase activity and genome methylation during F9 teratocarcinoma stem cell differentiation induced by polyamine deficiency. J Biol Chem, 272:4359-4366

22. Gritli-Linde A, Björkman U, Holm I, Törnell J and Linde A (1997) Constitutive activation of the polyamine pathway in bovine growth hormone transgenic mice. A causative phenomenon in pathological alterations? Cell Mol Endocrinol, 126:49-58.

23. Nilsson J, Koskiniemi S, Persson K, Grahn B and Holm I (1997) Polyamines regulate both transcription and translation of the ornithine decarboxylase antizyme gene in mouse. Eur J Biochem, 250:223-231.

24. Holm I, Mikhailov A, Jillson T and Rose B (1999) Dynamics of Gap Junctions Observed in Living Cells With Connexin43-GFP Chimaeric Protein. Eur J Cell Biol, 78:856-866.

25. Holm I, Collin H and Heby O, Maintenance of a high ornithine decarboxylase (ODC) mRNA level in nonproliferating parietal endoderm cells derived from teratocarcinoma stem cells by inhibition of their ODC activity. Manuscript in preparation.

26. Nilsson J and Holm I, Transcriptional regulation of the mouse antizyme inhibitor gene. Manuscript in preparation.
 
Meeting abstracts
A1. Holm I, Wallon M, Thorsson L and Heby O (1986) Methylglyoxal-bis(guanylhydrazone) (MGBG), an inhibitor of S-adenosylmethionine decarboxylase, interferes with alpha-difluoromethylornithine (DFMO)-induced growth arrest and differentiation of embryonal carcinoma cells. J. Cell. Biol. 101:246a.

A2. Heby O, Holm I, Oredsson SM, Thorsson L and Wallon M (1985) Highly malignant teratocarcinoma stem cells differentiate into parietal endoderm cells with no further proliferative potential upon inhibition of polyamine biosynthesis. Läkarsällskapets Riksstämma 1985, Älvsjö, Stockholm.

A3. Heby O, Wallon M, Holm I and Thorsson L (1986) Residual proliferative potential among teratocarcinoma cells induced to differentiate into parietal endoderm cells by polyamine synthesis inhibition. Proc. Am. Assoc. Cancer Res. 27:46.

A4. Persson L, Holm I and Heby O (1986) Translational regulation of ornithine decarboxylase by polyamines in Ehrlich ascites tumor cells. Abstract at the International Conference on Polyamines in Life Sciences, Lake Yamanaka, Japan.

A5. Heby O, Wallon M, Holm I, Thorsson L, Oredsson SM and Stjernborg L (1986) Polyamines in teratocarcinoma stem cell differentiation. Abstract at the International Conference on Polyamines in Life Sciences, Lake Yamanaka, Japan.

A6. Heby O, Persson L and Holm I (1987) Feedback regulation of ornithine decarboxylase translation by putrescine and spermidine. Ital J Biochem 36: 55A-56A.

A7. Holm I, Persson L and Heby O (1987) Ornithine decarboxylase (ODC) gene amplification and ODC overproduction in -difluoromethyl-ornithine-resistant tumor cells. Proc Am Assoc Cancer Res 28: 8.

A8. Heby O, Holm I, Wallon M and Thorsson L (1987) Role of polyamines in the regulation of teratocarcinoma stem cell growth and differentia-tion. Effects of polyamine depletion on DNA methylation. Abstract at Capri Lectures in Biotechnology: Regulation of Mammalian Cell Growth, Capri, Italy.

A9. Persson L, Holm I and Heby O (1987) Translational control of ornithine decarboxylase by polyamines. Abstract at Cold Spring Harbor Laboratory Meeting on Translational control. Cold Spring Harbor, New York.

A10. Persson L, Holm I, Ask A and Heby O (1988) Polyamine uptake from the host - A mechanism by which tumor cells may overcome the anti-proliferative effect of a polyamine synthesis inhibitor. Proc Am Assoc Cancer Res 29: 345.

A11. Holm I, Persson L, Stjernborg L and Heby O (1988) Regulation of ornithine decarboxylase mRNA translation through modulation of the intracellular spermidine level. FASEB J 2: A1562.

A12. Holm I, Persson L, Heby O and Seiler N (1988) Polyamine-mediated control of ornithine decarboxylase synthesis: Analyses using 1,4-di-methylputrescine and 5,8-dimethyl-spermidine. Abstract at the 4th International Congress of Cell Biology, Montréal.

A13. Holm I, Persson L, Stjernborg L and Heby O (1988) Polyamines regulate the efficiency of ornithine decarboxylase mRNA translation. Abstract at BioScience 88. Malmö.

A14. Persson L, Holm I and Heby O (1988) Analysis of the polyamine-mediated control of ornithine decarboxylase (ODC) mRNA translation using a cell line with an amplified ODC gene. Abstract at BioScience 88. Malmö.

A15. Ask A, Persson L, Holm I and Heby O (1988) Deficiency in polyamine uptake of a mutant L1210 cell line selected for resistance to methyl-glyoxal bis(guanylhydrazone) (MGBG), a potent anticancer agent. Abstract at BioScience 88. Malmö.

A16. Oredsson SM, Nicander B, Holm I and Heby O (1988) Ribonucleotide reductase activity and deoxyribonucleotide levels are increased in Ehrlich ascites tumor cells inhibited in their growth by polyamine depletion. Abstract at BioScience 88. Malmö.

A17. Wallon M, Zuretti MF, Holm I, Persson, L and Heby O (1988) Transcriptional and translational control of ornithine decarboxylase expression during the cell cycle. Abstract at the International Symposium on Polyamines in Biochemical and Clinical Research. Sorrento, Italy.

A18. Holm I, Persson L, Stjernborg L and Heby O (1988) Polyamines regulate the efficiency of ornithine decarboxylase mRNA translation by coordinately affecting the rates of initiation and elongation. Abstract at the International Symposium on Polyamines in Biochemical and Clinical Research. Sorrento, Italy.

A19. Persson L, Stjernborg L, Holm I and Heby O (1988) Feedback control of S-adenosylmethionine decarboxylase at the translational level. Abstract at the International Symposium on Polyamines in Biochemical and Clinical Research. Sorrento, Italy.

A20. Holm I, Persson L, Heby O and Seiler N (1988) Use of non-metabolizable methyl-substituted polyamine analogs in studies of polyamine-mediated ornithine decarboxylase (ODC) and S-adenosyl- methionine decarboxylase (AdoMetDC) regulation. Abstract at the International Symposium on Polyamines in Biochemical and Clinical Research. Sorrento, Italy.

A21. Heby O, Smith SS, Persson L, Stjernborg L, Holm I, Wallon M and Thorsson L (1988) Polyamine depletion may induce teratocarcinoma stem cell differentiation by causing DNA hypomethylation. Abstract at the Third Conference on Differentiation Therapy. Villasimius, Sardinia, Italy.

A22. Ask A, Heby O, Holm I and Persson L (1988) Kurativ effekt av poly-aminsynteshämmare vid behandling av leukemibärande möss. En konsekvens av försämrat polyaminupptag. Abstract at XLV Läkaresällskapets Riksstämma, Stockholm.

A23. Stjernborg L, Holm I, Persson L and Heby O (1989) Studies on ornithine decarboxylase mRNA distribution in polysome profiles using an L1210 cell line with an amplified ornithine decarboxylase gene. Abstract at the 19th FEBS Meeting, Rome.

A24. Heby O, Persson L, Ask A, Holm I and Smith SS (1989) Polyamines and DNA methylation in cell growth and differentiation. Abstract at the 19th FEBS Meeting, Rome.

A25. Persson L, Autelli R, Holm I and Heby O (1990) Ornithine decarboxylase expression: Studies using a polysomal run-off system. J Cell Biochem Suppl. 14C: CH313.

A26. Stjernborg L, Holm I, Persson L and Heby O (1990) Polyamine-mediated regulation of ornithine decarboxylase. Analysis of ornithine decarboxylase mRNA distribution in polysome profiles. J Cell Biochem Suppl. 14C: CH317.

A27. Heby O, Stjernborg L, Holm I, Autelli R and Persson L (1990) Control of ornithine decarboxylase and S-adenosylmethionine decarboxylase expression by polyamines. Abstract at the 635th Meeting of the Biochemical Society. Aberdeen.

A28. Collin H, Holm I and Heby O (1990) Maintenance of a high ornithine decarboxylase (ODC) mRNA level in nonproliferating parietal endoderm cells derived from teratocarcinoma stem cells by inhibition of their ODC activity. Abstract at the International Symposium on Polyamines in Molecular and Medical Biology. Kyoto.

A29. Heby O, Holm I, Collin H, Ek C, Frostesjö L, Bjersing J, Rehnholm A, Grahn B, Ask A, Stjernborg L and Persson L (1991) Polyamines: metabolic regulators affecting cell growth and differentiation. Abstract at Falk Symposium No.62 on Polyamines in the Gastrointestinal Tract. Titisee, Germany.

A30. Persson L, Lövkvist E, Stjernborg L, Ask A, Holm I and Heby O (1991) Regulatory mechanisms in polyamine metabolism. Abstract at Falk Symposium No.62 on Polyamines in the Gastrointestinal Tract. Titisee, Germany.

A31. Heby O, Holm I, Frostesjö L, Collin H, Rehnholm A, Grahn B and Persson L (1992) Polyamine synthesis inhibitors as inducers of F9 teratocarcinoma stem cell differentiation. Proc Am Assoc Cancer Res, in press.

A32. Frostesjö L, Grahn B, Holm I and Heby O (1992) DNA hypomethylation - A consequence of polyamine depletion and a possible cause of differentiation of F9 teratocarcinoma stem cells. Abstract at the Seventh International Conference of the International Society of Differentiation. Helsinki.

A33. Heby O, Ask A, Holm I, Rehnholm A, Frostesjö L and Persson L (1992) Development of resistance to hydroxyurea during treatment of human myelogenous leukemia K562 cells with alpha-difluoromethylornithine. A result of co-amplification of the genes for ornithine decarboxylase and ribonucleotide reductase R2 subunit. International Symposium on Polyamines in Cancer. Montgomery, Texas.

A34. Frostesjö L, Nilsson P, Bjersing J, Holm I and Heby O (1993) Genome-wide loss of DNA methylation in tumor cells induced to differentiate by inhibition of polyamine synthesis. Abstract at rhe 22nd FEBS Meeting. Stockholm.

A35. Persson K, Heby O and Holm I (1994) Intronless mouse gene coding for a functional S-adenosylmethionine decarboxylase. Abstract at the 16th Annual Conference on the Organization and Expression of the Genome. Lorne, Victoria, Australia.

A36. Heby O, Holm I, Frostesjö L and Bjersing J (1994) DNA hypomethylation: An effect of polyamine depletion and a possible cause of tumor cell differentiation. Abstract at the 16th Annual Conference on the Organization and Expression of the Genome. Lorne, Victoria, Australia.

A37. Heby O, Ask A, Persson L, Brorsson A, Frostesjö L and Holm I (1994) Development of resistance to hydroxyurea during treatment of human cancer cells with alpha-difluoromethylornithine. A result of coamplification of genes for ornithine decarboxylase and ribonucleotide reductase. Proc Am Assoc Cancer Res 35:9

A38. Rosander U C, Holm I, Grahn B, Løvtrup-Rein H, Mattsson M-O and Heby O (1994) Down-regulation of ornithine decarboxylase by a change in enzyme degradationduring gastrulation of Xenopus laevis. Abstract at the 8th International Conference of the International Society of Differentiation, Hiroshima, Japan.